PRESENTATION:  Methylcobalamin  750 mgand Pregabalin  75 mgTablets.

DRUG CLASS: Cobalamin derivative (methylcobalamin), Anticonvulsant/Analgesic (Pregabalin)

MECHANISM OF ACTION: Methylcobalamin works by functioning in the production of a material called myelin, which covers and protects nerve fibers. 

Pregabalin binds to alpha2-delta subunit of voltage-gated calcium channels within the CNS and modulates calcium influx at the nerve terminals, thereby inhibiting excitatory neurotransmitter release including glutamate, norepinephrine (noradrenaline), serotonin, dopamine, substance P, and calcitonin gene-related peptide.

Although structurally related to GABA, it does not bind to GABA or benzodiazepine receptors. Exerts antinociceptive and anticonvulsant activity.

Pregabalin may also affect descending noradrenergic and serotonergic pain transmission pathways from the brainstem to the spinal cord.

INDICATIONS & DOSAGE: As Directed by the Physician